MD-Gem
The Maryland Genetics, Epidemiology, and Medicine Training Program

Fellows

Leandros Boukos

My research interests focus on the role of the human epigenetic machinery in human homeostasis. Specifically, I am studying fundamental properties of genes encoding for chromatin modifiers, such as their expression patterns, their tolerance to variation, and their links to specific disease phenotypes. Additionally, I am working on Kabuki syndrome, one of the Mendelian disorders of the epigenetic machinery, where my focus is on characterizing the epigenomic aberrations that occur downstream of the genetic defect and give rise to the disorder.

Fei Chen

My primary interests are in genetics of pancreatic cancer and their interactions with environmental risk factors including smoking and alcohol. My dissertation is aimed to understand the genetic connections between chronic pancreatitis, diabetes and pancreatic cancer. I am also working on exome array and exome sequencing data of eye diseases and infectious diseases, conducing linkage and association analysis in population and family-based cohorts.

Michael Chou

Broadly, I am interested in population genetics and how genetic and genomic information is used. My current research involves analysing structural variation in Hirschsprung Disease, a neurodevelopmental birth defect.

Kipper Fletez-Brant

My research interests include questions of basic biology such as effects of person-to-person variability of histone marks and other biological processes, as well as more clinical concerns such as factors of host susceptibility to disease. I am also engaged in the characterization of technologies used to answer these questions.

Weiyan Li

I am interested in how genetics affects complex human diseases on its own and by gene-environment interaction. I am particularly interested in studying epigenetics as the intermediate layer between genes and environment. Also, I have an interest in early life exposures, especially how it may impact disease onset later in life through genetic, epigenetic or other mechanisms.

Entered Program: 2013

Ryan Longchamps

My research interests focuses on the role of the mitochondrial genome in the etiology of cardiovascular disease – particularly sudden cardiac death (SCD). Recent research in the Arking lab has shown mitochondrial DNA copy number (mtDNA-CN) to be associated with SCD as well as prevalent frailty and all-cause mortality. I am interested in elucidating the control mechanisms and genetics determinants for mtDNA-CN and how these factors may contribute to disease onset later in life.

Rebecca Mitchell

The focus of my research is on variation in mitochondrial DNA, including mtDNA copy number, heteroplasmy, and inherited genetic variation. I have been investigating the association of this variation with epigenetic modifications, specifically methylation, and the effect of this variation on physical function and aging-related disease (such as phenotypes associated with reduced mtDNA copy number).

Fellows (Click on an individual for more information)
Leandros Boukos Photo

Leandros Boukos

Fei Chen Photo

Fei Chen

Michael Chou Photo

Michael Chou

Kipper Fletez-Brant Photo

Kipper Fletez-Brant

Weiyan Li Photo

Weiyan Li

Ryan Longchamps Photo

Ryan Longchamps

Rebecca Mitchell Photo

Rebecca Mitchell

Associates
Woori Kim Photo

Woori Kim

Former Fellows
Name Year
Clementine Fu 2015
Johanna Robertson 2016
Shan Andrews 2017