MD-GEM is a pre-doctoral training program that comprehensively integrates Genetics, Epidemiology, and Medicine (GEM). Funded by the Burroughs-Wellcome Fund, the MD-GEM training grant brings together the expertise and training infrastructure of the Johns Hopkins Schools of Public Health and Medicine and the National Human Genome Research Institute. Together, these three institutions can provide laboratory, methodological and clinical expertise and coursework to train the next generation of scientists who can forge new avenues of research and address the rapidly changing field of human genetics. This program trains pre-doctoral students through integration of these important areas by partnering with established mentors and offering integrated learning. We envision a training program that will prepare scientists for the next generation of genetics research.